1. Jamaal Charles vs. NYG – The Giants D is not stopping anyone these days. Charles will top 125 yards with multiple TDs in Week 4.
2. Adrian Peterson vs. Pit – Look for Peterson to get back on track against a different Steelers D than we’re used to seeing.
3. Alfred Morris vs. Oak. It’s the Raiders.
4. LeSean McCoy vs. Den – McCoy’s stock through the roof in Kelly’s offense. He will give the Broncos D fits.
Not too far behind
Chris Johnson vs. NYJ – The shifty RB is running almost like the Johnson of old.
Doug Martin vs. Arz – The only way the Bucs will get back on track is by feeding Martin the ball 25+ times. The Cardinals will have trouble keeping him under 100.
Marshawn Lynch vs. Hou – He was given a sort of off-week vs. the Jags. He will top 100 yards with a TD here.
Rounding things out
Matt Forte vs. Det – Forte’s style will result in big overall yardage at Detroit.
Knowshon Moreno vs. Phi – The Eagles D is suspect at every level. Moreno will thrive even running behind a banged up line.
Reggie Bush vs. Chi – It looks like he’ll be back on Sunday and involved in the passing game.
Frank Gore vs. Stl – The real question is whether the 49ers will feed him the ball. They surprisingly went away from him after a solid 1st quarter a week ago.
DeMarco Murray vs. SD – Look for Murray to follow up an excellent game in Week 3 with another 100 yard effort at San Diego.
Giovani Bernard vs. Cle – The Browns don’t give up many rushing yards but Bernard is proving to be a stout goal line threat already.
Bilal Powell vs. Ten – He’ll be the top dawg this week against this Titans D.
Lamar Miller vs. NO – He will be used as a threat out of the backfield on Monday.
Maurice Jones-Drew vs. Ind – MJD is about the only thing to like right now on this offense.
Ahmad Bradshaw vs. Jax – He’ll still see the majority of carries while Richardson learns the system.
Darren McFadden vs. Was – The Skins D is in a state of disarray.
Ray Rice vs. Buf – Make sure he is back but if so, he will be good to go.
Stevan Ridley vs. Atl – The return of some offensive weapons will open up running lanes for Ridley.
Darren Sproles vs. Mia – The Fins D is pretty stingy but susceptible to scat backs.
Jacquizz Rodgers vs. NE – He’s a solid flex play while Jackson is out.
Potential Bust – Beware
Arian Foster vs. Sea – The Seahawks are deep and talented at each phase of the D. Foster is also now without his LT.