1. Adrian Peterson vs. Chi – Historically, Peterson has lit up the Bears in Chicago.
2. LeSean McCoy vs. SD – Expect McCoy to top over 150 yards with multiple TDs against the Chargers.
3. Arian Foster vs. Ten – 100 yards and 1-2 TDs as the Texans ground game will get rolling in this one. Foster was getting his feet under him in Week 1.
4. Jamaal Charles vs. Dal – The Cowboys will chase Charles all over the field.
Not too far behind
Doug Martin vs. NO – Tampa will pound Martin to keep Brees and Co. on the sidelines. He’ll respond with a 100 yard game.
Reggie Bush vs. Arz – The Lions plan to use him in multiple ways which bodes well for fantasy owners.
Matt Forte vs. Min – The Vikings are banged up defensively which will help out Forte’s production in this one.
Rounding out the rest
Ray Rice vs. Cle – His value is likely to come as a receiver out of the backfield.
CJ Spiller vs. Car – The Panthers run D is much improved but look for Spiller to break some long ones this week.
Stevan Ridley vs. NYJ – Look for Ridley to get out of Belichick’s doghouse in a big way on Thursday.
Demarco Murray vs. KC – The Boys will ride Murray for over 20 touches en route to a big afternoon.
Alfred Morris vs. GB – Morris will be a load for the Packers front.
Reggie Bush vs. Arz – Bush will have another monster game as a receiver this week.
Darren McFadden vs. Jax – Pryor’s presence has opened things up for McFadden and this is an easy match-up for #20.
Marshawn Lynch vs. SF – Lynch did have big games in both contests a year ago.
Steven Jackson vs. Stl – Not much in Week 1 outside of one long run. Expect about the same in this one.
Trent Richardson vs. Bal – Weeden’s play did Richardson in more than anything else. Look for a 7-10 fantasy point game in this one.
Frank Gore vs. Sea – Gore’s found big holes to run through playing Sea in recent years.
Ryan Matthews vs. Phi – He’ll find running against this D easier than Houston.
Eddie Lacy vs. Was – The big back will find the end zone a 2nd consecutive week.
Maurice Jones Drew vs. Oak – The Jags are abysmal, but QB Chad Henne brings some respectability to the offense which will help MJD.
Chris Johnson vs. Hou – Johnson’s had a history of running well against his rival.
David Wilson vs. Den – This is a risky fantasy football pick after his week 1 issues, but NYG won’t abandon ship and the 2nd year back could find a lot of room to run on Sunday.
Lamar Miller vs. Ind – The Colts D is horrible vs. the run, so Miller has fewer excuses this week.
Potential Bust – Beware
Vick Ballard vs. Mia – The Dolphins D smothered RB Trent Richardson in Week 1.