1. Adrian Peterson vs. Det – All Day will eclipse 125 yards and 2 TDs vs. the Lions.
2. Ray Rice vs. Den – The Ravens will want to control the clock and pound away at the Broncos depleted D.
3. Jamaal Charles vs. Jax – Charles is licking his chops here.
4. Arian Foster vs. SD – He will be fully healthy and facing a soft Chargers D.
Not far behind
Alfred Morris vs. Phi – The Eagles D is horrible and Morris will run them over.
Steven Jackson vs. NO – The Saints D will be one of the worst in the NFL. Look for Jackson to top 100 yards with a TD.
Trent Richardson vs. Mia – The Dolphins will be improved, but so will the Browns. Richardson will bully his way to the century mark with a score.
Rounding things out
Marshawn Lynch vs. Car – Expect around 100 yards and a score.
Stevan Ridley vs. Buf – The Patriots should be playing with a very large lead which bodes especially well for Ridley.
David Wilson vs. Dal – The blazer will also be the full-time back now.
Frank Gore vs. SF – Expect the 49ers massive front to engulf the Packers D and for Gore to find plenty of running room.
CJ Spiller vs. NE – The explosive Spiller will have a tough time playing with a rookie QB at the helm.
Demarco Murray vs. NYG – Murray has always run powerful and well against the Giants.
LeSean McCoy vs. Was – McCoy is one of the best in the business when healthy. Expect Chip Kelly to involve him early and often in this offense.
Darren Sproles vs. Atl – This will be a passing affair. Sproles will see a lot of balls his way.
Chris Johnson vs. Pit – This isn’t the Steelers D of old.
Maurice Jones-Drew vs. KC – MJD is a 100 yard candidate facing KC.
Doug Martin vs. NYJ – The Jets run D is pretty good, but Martin will be fed the ball 20+ times.
Reggie Bush vs. Min – His value will come as a receiver.
Matt Forte vs. Cin – The Bengals feature one of the best units in the NFL this year.
Potential Bust – Beware
Ryan Mathews vs. Hou – Matthews has had all sorts of fumbling issues and faces a very stout test in the Texans.